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The SSALC is established to characterize HIV/AIDS-related lymphoma and the indigenous background of lymphomas in sub-Saharan Africa from which these HIV/AIDS-related lymphomas arise. The SSALC plans to provide training in the current World Health Organization (WHO) classification of lymphomas to consortium participating pathologists from three regions of sub-Saharan Africa.

 

Sub-Saharan Africa is the origin of the HIV/AIDS epidemic and contains more than twice the number of cases than the rest of the world combined. Yet the HIV epidemic in Africa and associated increase in cancers such as lymphoma has been sparsely documented. A survey of lymphoid neoplasm subtype trends in the US, 1992-2001, found that subtypes defined by the WHO classification varied in prevalence by whether patients were African, Asian or European in ancestry. Findings suggest there is etiologic heterogeneity in lymphoma with risk factors and treatment modalities better defined by analysis of subtypes in more homogeneous populations, particularly those phenotypes associated with HIV/AIDS.

 

Pathologists from ten African sites representing East, West and South sub-Saharan regions will contribute small tissue cores from 100-200 individual cases for the construction of tissue microarrays (TMA). TMA construction and phenotyping tests will be directed by the participating pathologist and slides digitized during training in Columbus, Ohio, USA. Specimens from 1000-2000 patients will be characterized by the participants consulting with US hematopathologists. Participants in US and Africa will exchange information and images using a secure Internet workspace. An expert panel will review and arbitrate difficult or unusual lymphoma phenotypes. Illustrative lymphoma cases will be published in public web pages and all will be available for review on member private spaces.

 

The SSALC is funded by a grant from the National Cancer Institute (NCI, Washington DC, USA) to the Mid-Region AIDS and Cancer Specimen Resource (MR-ACSR, Columbus, Ohio, USA).

 

The SSALC Internet workspace is on-line at www.ssalc.org with private and public areas.

 

Presentations have been made at several conferences; see our full list of Publications.

 

A presentation was made at the AIDS Malignancy Consortium (AMC) Investigator’s Spring Meeting on April 29, 2010 in Bethesda, MD, USA:

 

A presentation was made at the Biospecimen Research Network (BRN) Symposium March 24, 2010 in Bethesda, Maryland, USA:

 

A presentation was made at the AORTIC 2009 conference November 11-14 in Dar es Salaam, Tanzania:

 

A presentation [abstract] was made at the APECSA 2008 conference October 22-25 in Mombasa, Kenya:

 

A presentation was made at the 8th INCTR 2009 meeting on March 23 in Antalya, Turkey:

Contact


Leona Ayers, M.D.
Principal Investigator
Sub-Saharan Africa Lymphoma Consortium (SSALC)
Mid-Region AIDS and Cancer Specimen Resource (ACSR)
Department of Pathology
The Ohio State University
Innovation Centre
2001 Polaris Parkway
Columbus, Ohio 43240
1 (614) 293-8106 voice
1 (614) 293-8130 fax
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Dave Nohle
SSALC, Mid-Region ACSR Web Site Administrator
Department of Pathology
The Ohio State University
Innovation Centre
2001 Polaris Parkway
Columbus, Ohio 43240
1 (614) 293-3554 voice
1 (614) 293-8130 fax
This email address is being protected from spambots. You need JavaScript enabled to view it.

FAQ

Why characterize lymphomas from sub-Saharan Africa?
Over two thirds of the world's HIV/AIDS cases occur there. Determining the frequency of sub-types in the general population should not only allow treatment improvements in the HIV negative population but will allow us to better anticipate cancers that will arise in HIV positive cases.

 

What is WebSlide?
WebSlide is a basic web-page-based virtual slide viewer (part of the Aperio Spectrum Plus ImageServer used to serve up images on the SSALC web site). WebSlide will be used by default when you view an image unless you have installed ImageScope. [brief WebSlide instructions]

 

What is ImageScope?
ImageScope is a full-featured image viewer (freely available from Aperio) that can optionally be used to view and work with virtual slide images. To use ImageScope, it must be installed on your computer. [download ImageScope from Aperio]

 

How can I work with copies of images (.svs or ScanScope Virtual Slide format) that are on my PC or hard drive?
Install the ImageScope, a full-featured image viewer (freely available from Aperio), on your computer. [download ImageScope from Aperio] Once ImageScope is installed you can double click on any .svs image file and ImageScope will start up and display the image. (You can also start ImageScope typically by pressing the Start button, selecting Programs, the ScanScope folder then ImageScope.)

 

What histologic stains are used with SSALC cases to differentiate WHO lymphoma sub-types?
The list is still a work in progress which is expanding as cases are added and sub-types are documented. [current stains]

Member Pathologists/Institutions

Pathologists practicing in sub-Saharan Africa are being recruited. Their institution will be listed here as a member of the SSALC and will have a public web page as well as private web pages for information that they wish to share only within the consortium.

SSALC members:

East Region

    • Dr. Lynnette Kyokunda Tumwine, Makerere University, Kampala, Uganda
      This email address is being protected from spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need JavaScript enabled to view it.

    • Dr. Ndungu Joseph Rugumi, University of Nairobi, Nairobi, Kenya
      This email address is being protected from spambots. You need JavaScript enabled to view it.

    • Dr. David Kiprop Chumba, Moi University, Eldoret, Kenya
      This email address is being protected from spambots. You need JavaScript enabled to view it.
West Region

    • Dr. Yawale Iliyasu, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
      This email address is being protected from spambots. You need JavaScript enabled to view it.


South Region


    • Dr. Akin E Abayomi, Stellenbosch University, Cape Town, South Africa
      This email address is being protected from spambots. You need JavaScript enabled to view it.


 

SSALC collaborators:

Europe

  • Dr. Kikkeri Naresh, Imperial College London, London, England, UK
    This email address is being protected from spambots. You need JavaScript enabled to view it. (with co-PI: Dr. Mark Bower, This email address is being protected from spambots. You need JavaScript enabled to view it.)

UNIVERSITY

This email address is being protected from spambots. You need JavaScript enabled to view it. is the the PI and SSALC Pathologist at Ahmadu Bello University Teaching Hospital, Zaria, Nigeria in the West Region of sub-Saharan Africa. Dr. Iliyasu is the current Secretary General of the (Anglophone) West African Division of International Academy of Pathology. Dr. Iliyasu visited Columbus the week of May 16, 2010 to participate in WHO lymphoma subtyping training with Dr. Ayers. (Dr. Iliyasu's visit was re-scheduled for the week of May 16 due to flight cancellations.)


The following abstract/poster was presented at APECSA 2010:

Epstein-Barr virus association with malignant lymphoma subgroups in Zaria, Nigeria
Yawale Iliyasu1,3, Leona W. Ayers2,3
1Department of Pathology, Ahmadu Bello University Teaching Hospital (Zaria, Nigeria)
2Department of Pathology, The Ohio State University Medical Center (Columbus, Ohio USA)
3Sub-Saharan Africa Lymphoma Consortium (SSALC/NCI)
[Abstract PDF] [Abstract Word DOC] [Poster PDF]

 


A poster for the following topic was presented at the April 2010 ICMAOI conference.

Malignant lymphoma subgroups from Zaria, Nigeria reveal absence of HIV/AIDS related plasmablastic lymphomas and HHV-8 related lymphoproliferative disorders
Yawale Iliyasu1,3, Weiqiang Zhao2,3, Leona W. Ayers2,3
1Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria, 800001
2Department of Pathology, The Ohio State University, Columbus, Ohio, 43210, USA
3Sub-Saharan Africa Lymphoma Consortium (SSALC/NCI)
[abstract PDF] [abstract Word] [poster PDF]